Among the most important and complex molecules in the human body, sugars control not just metabolism but also how cells communicate with one another. Graduating senior Jeffery Martin has put his basic knowledge of sugars to exceptional use by creating a lab-on-a-chip device that builds complex, highly specialized sugar molecules, mimicking one of the most important cellular structures in the human body — the Golgi Apparatus.

“Almost completely independently he has been able to come closer than researchers with decades more experience to creating an artificial Golgi,” said Robert Linhardt, the Ann and John H. Broadbent Jr. ‘59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering at Rensselaer and Martin’s adviser. “He saw a problem in the drug discovery process and almost instantly devised a way to solve it.”

Cells build sugars in a cellular organelle known as the Golgi Apparatus. Under a microscope, the Golgi looks similar to a stack of pancakes. The strange-looking organelle finishes the process of protein synthesis by decorating the proteins with highly specialized arrangements of sugars. The final sugar-coated molecule is then sent out into the cell to aid in cell communication and to help determine the cell’s function in the body.

Martin’s artificial Golgi functions in a surprisingly similar way to the natural Golgi, but he gives the ancient organelle a very high-tech makeover. His chip looks similar to a miniature checker board where sugars, enzymes, and other basic cell materials are suspended in water and can be transported and mixed by applying electric currents to the destination squares on the checker board. Through this process sugars can be built in an automated fashion where they are exposed to a variety of enzymes found in the natural Golgi. The resulting sugars can then be tested on living cells either on the chip or in the lab to determine their effects. With the chip’s ability to process many combinations of sugars and enzymes, it could help researchers quickly uncover new sugar-based drugs, according to Martin.

Scientists have known for years that certain sugars can serve as extremely beneficial therapeutics for humans. One well-known example is heparin, which is among the most widely used drugs in the world. Heparin is formed naturally in the Golgi organelle in cells of the human body as well as in other animals like pigs. Heparin acts as an anticoagulant preventing blood clots, which makes it a good therapeutic for heart, stroke, and dialysis patients.

The main source of heparin is currently the intestines of foreign livestock and, as recent news reports highlight, the risk of contamination from such sources is high. So researchers are working around the clock to develop a safer, man-made alternative to the drug that will prevent outside contamination. A synthetic alternative would build the sugar from scratch, helping eliminate the possibility of contamination he explained.

“I am very grateful to have the privilege of working with Dr. Linhardt who has discovered the recipe to make fully synthetic heparin,” Martin said. “Because we know the recipe, I am going to use it as a model to test the device. If our artificial Golgi can build fully functional heparin, we can then use the artificial organelle to produce many different sugar variants by altering the combination of enzymes used to synthesize them. Another great thing about these devices is that they are of microscale size, so that if needed we could fill an entire room with them to increase throughput for drug discovery.”

There are millions of possible sugar combinations that can be formed and scientists currently only know the function of very few of them like heparin. “Since it is known that these types of sugars play a part in many important biological processes such as cell growth, cell differentiation, blood coagulation, and viral defense mechanisms, we feel that that this artificial Golgi will help our team to develop a next generation of sugar-based drugs, known as glycotheraputics,” Martin said. “We are going to start making new combinations and we simply don’t know what we are going to find. We could find a sugar whose signal blocks the spread of cancer cells or initiates the differentiation of stem cells. We just don’t know.”

Martin, a Barry M. Goldwater Scholar and native of the small town of Boylston, Mass., is graduating from Rensselaer on May 17, 2008 with a nearly perfect GPA. He plans to continue on at Rensselaer as a graduate student, working with Linhardt to test and further develop his artificial Golgi.

[Gabrielle DeMarco @ Rensselaer Polytechnic Institute]

Motorola’s Z9 is a slider phone with a mahogany exterior, which is a nice color to differentiate the Z9 from the rest. The external controls continue to be standard with a volume rocker and music shortcut on the left spine, and a camera shutter and a microUSB port on the right spine. The front packs a gorgeous 2.4-inch display with 262k color support, a crispness that’s required to view today’s digital content, including videos, photos and text. We had a blast navigating through the menu just because the display was so vibrant and exciting to use. Of course similar to a lot of smartphones, you can adjust the brightness and backlighting time to conserve battery, and trust us, with the display this bright, you are almost certainly going to have to work on reducing the brightness.

Going back to the navigation menu, do note that Motorola hasn’t updated its menu at all. It’s the same old way of browsing through your phone. We’re not pleased; half of the fun of getting a new phone is to take advantage of new features, and the Z9 is lackluster in that category.

Underneath the display is your OK button with four corresponding keys for navigation. Additionally, there are two soft keys, Talk/End-Power keys, a Clear-Back key and a Web browser shortcut key to further occupy the rest of the device.

Once you slide open the phone, you are welcomed to its keypad with alphanumeric keys. All keys offer tactile feedback that are difficult to feel. The keys underneath the display, especially, didn’t offer the best tactile feedback that we have experienced. Motorola needs to work on getting the most basic necessities of the phone right.

On the back, you will find the integration camera with its lens and flash. It’s a 2.0-megapixel camera with support for four resolutions (1,600×200, 1,280×960, 640×480, 320×240), three quality settings and 8x digital zoom. Other options, such as lighting (five), color tones (six), and exposure metering are all present. You can also record video in three resolutions (320×240, 176×144 and 128×96) with three quality settings. You can record for up to 30 seconds for MMS clips, or for an unlimited amount of time depending on onboard storage. The phone is equipped with 45MB of onboard storage + a microSD expandable slot for additional memory. There’s a memory meter to alert of you of total available memory, a delightful option.

The Z9 lacks a mirror, so taking self-portraits would be an interesting task at best. The camera quality was decent. It took crisp pictures, but there was some blurriness in them due to dull lighting. Even in the brightest of times, the photo quality didn’t quite get the colors right. While sharp, there were some issues with color contrast in our testing. We would qualify the overall quality to be good with reservations, or decent.

Motorola’s Z9 feels good when you are holding it, as it’s a sturdy, solid unit.

In addition to the onboard camera, it packs an alarm clock, a calendar, text and multimedia messaging and a host of other default, expected features. Most notable is AT&T’s Navigator GPS application, AT&T’s Video Share service, AT&T Music (thanks to 3G support), and a music player with support for MP3, AAC and WMA formats; playlists, shuffle and repeat modes; it also packs a host of mobile multimedia (music, video and weather) services to round out its features set. We liked the feature set in general. Although it’s limited in its potential, Motorola did its best to include as many applications as the phone would hold.

On the performance side, in one word: “Excellent!” The Z9 is an amazing phone with its excellent audio quality. We had no problem understanding callers, or vice versa, thanks to Motorola’s CrystalTalk and auto background noise canceling technology. The phone automatically adjusted our volume depending on extraneous noise, which is something we are greatly fond of with Motorola handsets.

The speakerphone was good, but not quite there with standard output. The volume output was poor, and we really had to focus on what callers were saying to understand them. That defeats the point of turning on the speakerphone option.

Signal strength for 3G was superior and so were audio and video streaming. Though video quality was okay, it was expected. Our videos didn’t pause for buffer or any other technical issues. We loved interacting with our digital control through Z9 and its speedy connection. For some odd reason, however, loading time for music and video files was all over the graph. Some files took longer to load, while others were fairly rapid.

Volume output for audio on the phone was surprising good, especially with a headset.

The Z9 is rated for four hours of talk time and 13 days of standby time. We confirmed these numbers in our lab, and they were inline with the company’s estimates. Four hours is a little iffy for our taste considering it’s a multimedia phone with a handful of battery heavy options.

All in all, the Z9 is a very good phone with solid exterior and a host of features. It’s not the phone for consumers who are looking for mobile innovation, but if you just want a cell phone without a learning curve, but with a bit trendy design, the Z9 is a superb option.

[Gundeep Hora]

This article has been republished with the kind permission of our friends at CoolTechZone. For more news about the gadgets that make the world go ’round, go give ‘em a look or Subscribe to CoolTechZone’s RSS Feed!

Related Articles @ CoolTechZone:

• Virus Protection on Leopard? I Don’t Think So.
• Motorola RAZR V9
• Sony AS50G Headphones Review
• iPhone Competitors: What’s The Point Now?
• Nokia’s Last Effort to Revive N-Gage Fails